Lipozene: Benefits, Side Effects, Dosage, and Interactions

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Lipozene is advertised as a weight loss supplement. Its one active ingredient is a konjac root extract called glucomannan. Konjac glucomannan is a dietary fiber that is popular in both Asian and European countries, especially in flour form.

Health Benefits

The primary health benefit Lipozene claims to offer is weight loss. Carrying a higher-than-recommended weight has been associated with a number of major, and often chronic health conditions such as:

Excess weight also increases one's risk of death. Therefore, losing weight offers people who are overweight or obese the opportunity to lower these risks, maybe even saving or lengthening their lives.

The way Lipozene is said to help with weight loss is that glucomannan expands to more than 200 times its size when mixed with water. So, taking Lipozene works by filling the stomach. Because you feel full, it becomes easier to consume fewer calories. But does it work?

What the Research Shows

The Lipozene website contains references to clinical studies. But it doesn't provide any details about how the research was conducted or where it was published for evaluation by experts in the field. The site states: "Overweight persons in the active group and all persons in the first study lost on average at least 4.93 more lbs than placebo." It goes on to say that "78% of each pound lost was pure body fat."

That statement sounds impressive, but it's not clear how the body fat was measured. More importantly, you don't know what people had to do to lose weight. Perhaps the group taking Lipozene happened to exercise and cut calories more and the placebo group did not. Because the research was not published in a peer-reviewed scientific journal, there is no way to know if the study holds up to scrutiny.

On March 6, 2020, a class action lawsuit questioning the validity of Lipozene's weight loss claims reached a settlement whereby the company—which did not admit to any wrongdoing—agreed to pay a total of $4.6 million to class members for calling the supplement a "weight loss breakthrough" and saying that it would "get rid of pounds of body fat."

The company also references scientific studies about Amorphophallus konjac as evidence that the product is effective. This plant is the source of glucomannan, the active ingredient in Lipozene. Glucomannan is a water-soluble, fermentable dietary fiber. But studies regarding glucomannan show mixed results.

For example, one peer-reviewed study concluded that glucomannan did not promote weight loss when taken for eight weeks. Another review of current clinical trials concluded that some studies did show limited weight loss with glucomannan, but no long-term evidence and no change in body mass index.

Where glucomannan was found to be effective for weight loss was when it was combined with garcinia cambogia. One study found that taking 500 mg of each twice a day for six months resulted in weight loss and fat mass reduction. But was this due to the glucomannan or the garcinia cambogia?

According to one 2020 meta-analysis, glucomannan may have played a role. This piece of research looked at six different trials involving 225 total people and concluded that consuming glucomannan provided a "significant reduction in body weight."

Possible Side Effects

Because repeated clinical trials have not been able to definitively prove that glucomannan causes weight loss, the National Institutes of Health (NIH) has determined that glucomannan has "little to no effect on body weight."

The NIH also cautions users of the potential risks of taking glucomannan. Possible side effects include loose stools, flatulence, diarrhea, constipation, and abdominal discomfort.

Both the NIH and product packaging warn that taking glucomannan in tablet form may also obstruct the esophagus if it isn't consumed with adequate fluids. For this reason, it is further recommended that people with difficulty swallowing not take Lipozene.

Dosage and Preparation

Lipozene's suggested dosage is two capsules, up to three times a day, taken with at least eight ounces of liquid, and 30 minutes before a meal. Each two-capsule serving provides 1,500 mg of Amorphophallus konjac, so taking it as recommended means consuming 4,500 mg per day.

Because the purpose of glucomannan is to make a person feel more full, the most important part of taking Lipozene is that it must be before you eat. Also, be sure to drink enough water to get it down your throat before it starts to expand.

What to Look For

Whether buying Lipozene or any other weight loss supplement, the U.S. Food and Drug Administration (FDA) recommends avoiding products that:

  • Promise fast results or results that sound too good to be true
  • Say "guaranteed" or "scientific breakthrough"
  • Are marketed in a different language or through mass emails
  • Claim to be an herbal alternative to a drug approved by the FDA

Does Lipozene Work?

Since the active ingredient in Lipozene (fiber) doesn't magically speed up your metabolism or burn fat, you still have to eat less or exercise more to lose weight. You may be able to eat your favorite foods, as the website advertises, but you'll probably have to eat far less of them.

Fiber simply helps you to feel full so you get hungry less often. But many of us eat for reasons other than hunger—like boredom or stress. And if you're overweight, you may be eating foods that are higher in calories. Lipozene doesn't address any of those issues.

You can get fiber from other food sources (like whole grain bread, vegetables or fruit), without paying a lot of money for pills.

Is Lipozene Affordable?

To determine the real cost of Lipozene, you would need to calculate the cost of the pill per week and multiply it by the number of weeks that it will take you to reach your goal weight. But since you can't predict how long it will take to lose weight, there is no good way to calculate your total cost.

According to the company, you should take 2 pills before each meal, for a recommended maximum dose of 6 pills per day. When you sign up for Lipozene, you get a 60-pill supply (two 30-pill trial size bottles). The company calls this a 30-day supply, but if you take the dose they recommend (six pills per day), 60 pills will only last 10 days.

After the trial, the company sends you automatic shipments of 60-pill bottles at $29.95 each. The total cost, if you take the recommended dose, is roughly $90 per month—not including shipping or handling. 

Lipozene does offer a guarantee. The company says that if you don't lose weight with their product you can get your money back. But in order to return it, you need to contact the company within 30 days and get an authorization number.

A Word From Verywell

If you're in the market for a product to help you feel full so that you eat less and lose weight, skip the Lipozene and eat more fiber. You can get plenty of fiber from natural sources like fruits, veggies, and legumes. When you get nutrients from real food, you have the security of knowing what you're eating. And fresh produce, while sometimes expensive, is a lot cheaper than Lipozene.

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